• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

Lactic acid: New roles in a new millennium.

作者信息

Gladden L B

机构信息

Department of Health and Human Performance, Auburn University, Auburn, AL 36849-5323, USA.

出版信息

Proc Natl Acad Sci U S A. 2001 Jan 16;98(2):395-7. doi: 10.1073/pnas.98.2.395.

DOI:10.1073/pnas.98.2.395
PMID:11209043
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC33360/
Abstract
摘要

相似文献

1
Lactic acid: New roles in a new millennium.乳酸：新千年的新角色。
Proc Natl Acad Sci U S A. 2001 Jan 16;98(2):395-7. doi: 10.1073/pnas.98.2.395.
2
Clarifying the equation for modeling of VO2 kinetics above the lactate threshold.
J Appl Physiol (1985). 2010 Oct;109(4):1283-4. doi: 10.1152/japplphysiol.00459.2010.
3
What does glycolysis make and why is it important?糖酵解产生了什么，以及它为什么重要？
J Appl Physiol (1985). 2010 Jun;108(6):1450-1. doi: 10.1152/japplphysiol.00308.2010. Epub 2010 Mar 25.
4
Point: Muscle lactate and H⁺ production do have a 1:1 association in skeletal muscle.要点：骨骼肌中肌肉乳酸和H⁺的产生确实存在1:1的关联。
J Appl Physiol (1985). 2011 May;110(5):1487-9; discussion 1497. doi: 10.1152/japplphysiol.01506.2010. Epub 2011 Jan 6.
5
Counterpoint: Muscle lactate and H⁺ production do not have a 1:1 association in skeletal muscle.反驳观点：骨骼肌中肌肉乳酸和H⁺生成并非呈1:1关联。
J Appl Physiol (1985). 2011 May;110(5):1489-91; discussion 1498. doi: 10.1152/japplphysiol.01506.2010a.
6
Rebuttal from Robergs.罗伯格斯的反驳。
J Appl Physiol (1985). 2011 May;110(5):1491-2. doi: 10.1152/japplphysiol.01506.2010c.
7
Shaking up glycolysis: Sustained, high lactate flux during aerobic rattling.撼动糖酵解：有氧颤抖期间持续的高乳酸通量。
Proc Natl Acad Sci U S A. 2001 Jan 16;98(2):723-8. doi: 10.1073/pnas.98.2.723. Epub 2000 Dec 19.
8
Rebuttal from Vinnakota and Kushmerick.维纳科塔和库什梅里克的反驳。
J Appl Physiol (1985). 2011 May;110(5):1491. doi: 10.1152/japplphysiol.01506.2010b.
9
Does energy demand have an additional control in ischemia or are current models of metabolic control adequate at extremes?能量需求在局部缺血中是否存在额外的调控机制，或者当前的代谢调控模型在极端情况下是否足够？
Adv Exp Med Biol. 1994;361:509-20. doi: 10.1007/978-1-4615-1875-4_90.
10
Comments on Point:Counterpoint: Muscle lactate and H⁺ production do/do not have a 1:1 association in skeletal muscle. Lactate and acidosis yet again?关于“正方观点：反方观点：骨骼肌中肌肉乳酸与H⁺生成存在/不存在1:1关联”的评论。乳酸与酸中毒再次被提及？
J Appl Physiol (1985). 2011 May;110(5):1495. doi: 10.1152/japplphysiol.00242.2011.

引用本文的文献

1
Lactate Metabolism in Health and Disease.健康与疾病中的乳酸代谢
Adv Exp Med Biol. 2025;1478:573-613. doi: 10.1007/978-3-031-88361-3_24.
2
Energetic responses of head-out water immersion at different temperatures during post-exercise recovery and its consequence on anaerobic mechanical power.不同温度下头部浸水在运动后恢复期间的能量反应及其对无氧机械功率的影响。
Eur J Appl Physiol. 2023 Dec;123(12):2813-2831. doi: 10.1007/s00421-023-05265-6. Epub 2023 Jul 1.
3
Sensitivity of High Conservation Value Birds to Para-Aminopropiophenone (PAPP) Determined by Sub-Lethal Dose-Response Assay.通过亚致死剂量反应试验确定高保护价值鸟类对对氨基苯丙酮（PAPP）的敏感性。
Animals (Basel). 2023 Jan 27;13(3):433. doi: 10.3390/ani13030433.
4
Lactate inhibits naked mole-rat cardiac mitochondrial respiration.乳酸抑制裸鼹鼠心脏线粒体呼吸。
J Comp Physiol B. 2022 Jul;192(3-4):501-511. doi: 10.1007/s00360-022-01430-z. Epub 2022 Feb 18.
5
Effects of Dietary Supplementation with Combination of Tributyrin and Essential Oil on Gut Health and Microbiota of Weaned Piglets.丁酸甘油酯与精油组合日粮添加对断奶仔猪肠道健康和微生物群的影响
Animals (Basel). 2020 Jan 21;10(2):180. doi: 10.3390/ani10020180.
6
Lactate up-regulates the expression of lactate oxidation complex-related genes in left ventricular cardiac tissue of rats.乳酸上调大鼠左心室心肌组织中乳酸氧化复合物相关基因的表达。
PLoS One. 2015 May 21;10(5):e0127843. doi: 10.1371/journal.pone.0127843. eCollection 2015.
7
Lactate promotes PGE2 synthesis and gluconeogenesis in monocytes to benefit the growth of inflammation-associated colorectal tumor.乳酸可促进单核细胞中前列腺素E2的合成及糖异生作用，从而有利于炎症相关的结直肠癌生长。
Oncotarget. 2015 Jun 30;6(18):16198-214. doi: 10.18632/oncotarget.3838.
8
Lactate and the lactate-to-pyruvate molar ratio cannot be used as independent biomarkers for monitoring brain energetic metabolism: a microdialysis study in patients with traumatic brain injuries.乳酸及乳酸与丙酮酸的摩尔比不能作为监测脑能量代谢的独立生物标志物：一项针对创伤性脑损伤患者的微透析研究。
PLoS One. 2014 Jul 15;9(7):e102540. doi: 10.1371/journal.pone.0102540. eCollection 2014.
9
Randomized controlled trial of Micro-Mobile Compression® on lactate clearance and subsequent exercise performance in elite male cyclists.Micro-Mobile Compression®对精英男性自行车运动员乳酸清除率及后续运动表现影响的随机对照试验
Open Access J Sports Med. 2013 Oct 16;4:221-7. doi: 10.2147/OAJSM.S51956. eCollection 2013.
10
Variability of coordination parameters at 400-m front crawl swimming pace.400 米自由泳划频变化对协调参数的影响。
J Sports Sci Med. 2009 Jun 1;8(2):203-10. eCollection 2009.

本文引用的文献

1
Lactic acid in amphibian muscle.两栖动物肌肉中的乳酸
J Physiol. 1907 Mar 27;35(4):247-309. doi: 10.1113/jphysiol.1907.sp001194.
2
DETECTING THE THRESHOLD OF ANAEROBIC METABOLISM IN CARDIAC PATIENTS DURING EXERCISE.检测心脏病患者运动时无氧代谢的阈值。
Am J Cardiol. 1964 Dec;14:844-52. doi: 10.1016/0002-9149(64)90012-8.
3
Acid-sensing ion channel 3 matches the acid-gated current in cardiac ischemia-sensing neurons.酸敏感离子通道3与心脏缺血感知神经元中的酸门控电流相匹配。
Proc Natl Acad Sci U S A. 2001 Jan 16;98(2):711-6. doi: 10.1073/pnas.98.2.711. Epub 2000 Dec 19.
4
Shaking up glycolysis: Sustained, high lactate flux during aerobic rattling.撼动糖酵解：有氧颤抖期间持续的高乳酸通量。
Proc Natl Acad Sci U S A. 2001 Jan 16;98(2):723-8. doi: 10.1073/pnas.98.2.723. Epub 2000 Dec 19.
5
Role of convective O(2) delivery in determining VO(2) on-kinetics in canine muscle contracting at peak VO(2).在犬类肌肉以最大摄氧量（VO₂）峰值收缩时，对流性氧气输送在决定VO₂动力学方面的作用。
J Appl Physiol (1985). 2000 Oct;89(4):1293-301. doi: 10.1152/jappl.2000.89.4.1293.
6
Intra- and extra-cellular lactate shuttles.细胞内和细胞外乳酸穿梭
Med Sci Sports Exerc. 2000 Apr;32(4):790-9. doi: 10.1097/00005768-200004000-00011.
7
Muscle as a consumer of lactate.肌肉作为乳酸的消耗者。
Med Sci Sports Exerc. 2000 Apr;32(4):764-71. doi: 10.1097/00005768-200004000-00008.
8
Cardiac and skeletal muscle mitochondria have a monocarboxylate transporter MCT1.心肌和骨骼肌线粒体含有单羧酸转运蛋白MCT1。
J Appl Physiol (1985). 1999 Nov;87(5):1713-8. doi: 10.1152/jappl.1999.87.5.1713.
9
The proton-linked monocarboxylate transporter (MCT) family: structure, function and regulation.质子偶联单羧酸转运体（MCT）家族：结构、功能与调控
Biochem J. 1999 Oct 15;343 Pt 2(Pt 2):281-99.
10
Role of protons in activation of cardiac sympathetic C-fibre afferents during ischaemia in cats.猫缺血期间质子在心脏交感C纤维传入神经激活中的作用。
J Physiol. 1999 Aug 1;518 ( Pt 3)(Pt 3):857-66. doi: 10.1111/j.1469-7793.1999.0857p.x.