Datta K, Sinha S, Chattopadhyay P
Department of Biochemistry, All India Institute of Medical Sciences, New Delhi 110029.
Natl Med J India. 2000 Nov-Dec;13(6):304-10.
With the advent of the use of oxygen as the terminal electron acceptor in aerobic respiration, came the curse in the form of reactive oxygen species (ROS). However, the evolving organism had developed elaborate defence machinery to escape from these reactive byproducts of its own metabolism, and also developed a mechanism for the utilization of these species in physiological processes to gain a survival advantage. ROS have been increasingly implicated in the ageing process and in different diseases such as cancer, Alzheimer's disease, Parkinson's disease, reperfusion injury, etc. They are also important in cellular phenomenon such as signal transduction pathways. We review the mechanisms of production of ROS in the cell, their interaction with cellular macromolecules, pathways of ROS-induced cell death, the mechanisms for protection from ROS-induced damage as well as the key biological and disease processes where ROS play an important role.
随着在有氧呼吸中使用氧气作为终端电子受体的出现，活性氧（ROS）形式的祸根也随之而来。然而，不断进化的生物体已经发展出了精巧的防御机制，以逃避自身新陈代谢产生的这些活性副产物，并且还开发出一种机制，在生理过程中利用这些物质以获得生存优势。ROS越来越多地与衰老过程以及癌症、阿尔茨海默病、帕金森病、再灌注损伤等不同疾病相关联。它们在细胞现象如信号转导途径中也很重要。我们综述了细胞中ROS的产生机制、它们与细胞大分子的相互作用、ROS诱导细胞死亡的途径、免受ROS诱导损伤的机制以及ROS发挥重要作用的关键生物学和疾病过程。
