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[儿童急性神经感染中髓鞘碱性蛋白抗体的诊断及预后意义]

[Diagnostic and prognostic significance of the antibodies to the myelin basic protein in acute neuroinfections in children].

作者信息

Petrukhin A S, Idrisova Zh R, Vorov'eva N L, Gervazieva V B, Dekonenko E P

出版信息

Zh Nevrol Psikhiatr Im S S Korsakova. 2001;101(1):41-4.

PMID:11209527
Abstract

The development of severe CNS damages including encephalitis is highly probable in some respiratory and exanthemata viral infections (measles, rubella, parotitis). A high level of IgG antibodies to the myelin basic protein was found in patients with parotitis meningitis and rubella encephalitis but it was not high in 80% of patients with encephalitis of the unclear etiology and in 25% of cases with rubella encephalitis. More accurate analysis of clinical, neurovisual and immunologic data revealed a link of appearance of such complications with both the presence of more pronounced demyelinization and prolongation of the disease.

摘要

在某些呼吸道和皮疹性病毒感染(麻疹、风疹、腮腺炎)中,很有可能发生包括脑炎在内的严重中枢神经系统损伤。在腮腺炎脑膜炎和风疹脑炎患者中发现了高水平的抗髓鞘碱性蛋白IgG抗体,但在80%病因不明的脑炎患者和25%的风疹脑炎病例中该抗体水平不高。对临床、神经视觉和免疫学数据进行更精确的分析发现,这些并发症的出现与更明显的脱髓鞘以及疾病的延长有关。

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