10% 羟乙基淀粉用于扩容治疗重度卵巢过度刺激综合征。病例报告。
10% hydroxyethyl starch for plasma expansion in the treatment of severe ovarian hyperstimulation syndrome. A case report.
作者信息
Rabinerson D, Ben Rafael Z, Keslin J, Zolotarsky V, Dekel A
机构信息
Department of Obstetrics and Gynecology and General Intensive Care Unit, Rabin Medical Center, Golda Campus, Petah Tiqva 49372, Israel.
出版信息
J Reprod Med. 2001 Jan;46(1):68-70.
BACKGROUND
Severe ovarian hyperstimulation syndrome is a complication of hormonal therapy for in vitro fertilization and carries the risk of renal failure. The injection of 6% hydroxyethyl starch has been used as a preventive measure.
CASE
A 33-year-old woman was admitted with severe ovarian hyperstimulation syndrome after receiving gonadotropins as part of our in vitro fertilization protocol. Despite treatment with saline, albumin and abdominal taps, oliguria developed on the third day. The patient was transferred to the general intensive care unit and treated with 10% hydroxyethyl starch, furosemide and a further abdominal tap. Recovery was rapid.
CONCLUSION
Ten percent hydroxyethyl starch is an efficient plasma expander. It is safe, biohazard free and cost-effective. It seems to effectively control severe ovarian hyperstimulation syndrome and to overcome acute prerenal failure. Larger prospective studies are necessary to further evaluate its role in the treatment of severe ovarian hyperstimulation syndrome.
背景
严重卵巢过度刺激综合征是体外受精激素治疗的一种并发症，存在肾衰竭风险。注射6%羟乙基淀粉已被用作预防措施。
病例
一名33岁女性在接受促性腺激素作为我们体外受精方案的一部分后，因严重卵巢过度刺激综合征入院。尽管接受了生理盐水、白蛋白治疗及腹腔穿刺放液，但在第三天出现了少尿。患者被转至综合重症监护病房，接受了10%羟乙基淀粉、呋塞米治疗及再次腹腔穿刺放液。恢复迅速。
结论
10%羟乙基淀粉是一种有效的血浆扩容剂。它安全、无生物危害且具有成本效益。它似乎能有效控制严重卵巢过度刺激综合征并克服急性肾前性肾衰竭。需要进行更大规模的前瞻性研究以进一步评估其在治疗严重卵巢过度刺激综合征中的作用。
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