Obrzut Bogdan, Kuczyński Waldemar, Grygoruk Cezary, Putowski Lechosław, Kluz Sabina, Skret Andrzej
Department of Obstetrics and Gynecology, County Specialistic Hospital, Rzeszow, Poland.
Gynecol Endocrinol. 2005 Jul;21(1):45-9. doi: 10.1080/09513590500099511.
We report the case of a 32-year-old woman suffering from severe liver dysfunction in the course of ovarian hyperstimulation syndrome (OHSS). Complications occurred after successful fertilization subsequent to ovarian stimulation with human menopausal gonadotropin followed by ovulation induction with human chorionic gonadotropin. Because of nausea, vomiting, abdominal distention and enlarged ovaries on an ultrasound examination, she was admitted on the diagnosis of OHSS. During the course of hospitalization severe hepatic injury developed. An increase of more than 100-fold in blood aminotransferase activity was observed. Applied treatment resulted in gradual reduction of ovarian size and resolution of ascites, as well as pleural and pericardial effusions. The patient was discharged from hospital after 46 days. Follow-up examinations at the 13th and 32nd weeks of gestation did not reveal any abnormalities. Pregnancy developed without complications and the woman went into spontaneous labor, giving birth to a viable child at 38 weeks' gestation. Taking into account the above case and previously published reports, the issue of liver dysfunction may have a great impact on the understanding both the pathology and the treatment of OHSS.
我们报告了一例32岁女性在卵巢过度刺激综合征（OHSS）过程中出现严重肝功能障碍的病例。在用绝经期促性腺激素刺激卵巢随后用人绒毛膜促性腺激素诱导排卵成功受精后出现了并发症。由于恶心、呕吐、腹胀以及超声检查发现卵巢增大，她因OHSS诊断入院。在住院期间出现了严重的肝损伤。观察到血液转氨酶活性增加了100倍以上。所采用的治疗使卵巢大小逐渐缩小，腹水以及胸腔和心包积液消退。患者在46天后出院。妊娠第13周和第32周的随访检查未发现任何异常。妊娠过程无并发症，该女性自然分娩，在妊娠38周时产下一个存活的婴儿。考虑到上述病例及先前发表的报告，肝功能障碍问题可能对理解OHSS的病理及治疗有重大影响。
