Arciola C R, Donati M E, Montanaro L
Research Laboratory on Biocompatibility of Implant Materials, Rizzoli Orthopedic Institute, Bologna, Italy.
New Microbiol. 2001 Jan;24(1):63-8.
The antibiotic-resistance both of adherent bacteria to polymethylmethacrylate (PMMA) and of bacteria which, although exposed to the material, had not undergone adhesion, was measured as bacterial growth inhibition area onto a plate antibiogram, according to Kirby-Bauer and using a dedicated image analyzer system. The adhesion onto PMMA induces a marked (about 30%) increase in resistance to beta-lactam antibiotics (cefamandole, cefazolin, imipenem and ampicillin) and a lower (about 15%) but significant increase to the macrolide erythromycin, to two aminoglycosides (amikacin, netilmicin) and to vancomycin, chloramphenicol and trimethoprim-sulfamethoxazole.
根据柯氏-鲍氏法并使用专用图像分析仪系统，通过测量平板抗菌谱上的细菌生长抑制面积，来测定附着于聚甲基丙烯酸甲酯（PMMA）的细菌以及虽接触该材料但未发生黏附的细菌的抗生素耐药性。黏附于PMMA会使对β-内酰胺类抗生素（头孢孟多、头孢唑林、亚胺培南和氨苄西林）的耐药性显著增加（约30%），对大环内酯类红霉素、两种氨基糖苷类抗生素（阿米卡星、奈替米星）以及万古霉素、氯霉素和甲氧苄啶-磺胺甲恶唑的耐药性也会有较低幅度（约15%）但显著的增加。
