双（氮丙啶基）磷酰基-N-羟基氨基甲酸酯衍生物作为抗肿瘤剂的合成。
Synthfsis of bis(aziridinyl)phosphinyl-N-hydroxyurethane derivatives as antineoplastic agents.
作者信息
Hsiao Y Y, Bardos T J, Wampler G L, Regelson W
出版信息
J Med Chem. 1975 Feb;18(2):195-8. doi: 10.1021/jm00236a019.
PMID:1120987
Abstract
Several new "dual antagonists" were synthesized in which the 2,2-dimethyl (or ring C unsubstituted) aziridine phosphinyl function is linked to N-hydroxyurethane rather than the urethane moiety. Three of the new compounds showed very high activities against leukemia L1210 in mice.
摘要
合成了几种新的“双拮抗剂”，其中2,2-二甲基（或环C未取代）氮丙啶磷酰基官能团与N-羟基氨基甲酸酯相连，而不是与氨基甲酸酯部分相连。三种新化合物对小鼠白血病L1210显示出非常高的活性。
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