寻找新型抗癌药物。VII. 二氮丙啶和氮杂环丁烷的铂配合物
In the search for new anticancer drugs. VII. Platinum complexes of diaziridines and azetidine.
作者信息
Sosnovsky G, Lukszo J
出版信息
J Cancer Res Clin Oncol. 1984;107(3):217-20. doi: 10.1007/BF01032610.
Abstract
Three new diaziridine platinum(II) complexes (4a)-(4c), and a new azetidine platinum(II) complex (3b) were synthesized and tested against the lymphocytic leukemia P388 in mice. (formula; see text) Moderate to good activity was found for all compounds as evidenced by a T/C value of 162 at a dose of 32 mg/kg for (3b), 190 at a dose of 32 mg/kg for (4a), 139 at a dose of 4 mg/kg for (4b), and 142 at a dose of 20 mg/kg for (4c).
摘要
合成了三种新型二氮丙啶铂（II）配合物（4a）-（4c）和一种新型氮杂环丁烷铂（II）配合物（3b），并在小鼠体内针对淋巴细胞白血病P388进行了测试。（分子式；见正文）所有化合物均表现出中等至良好的活性，（3b）在32mg/kg剂量下的T/C值为162，（4a）在32mg/kg剂量下为190，（4b）在4mg/kg剂量下为139，（4c）在20mg/kg剂量下为142，证明了这一点。
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