Temple E, Poldrack R A, Salidis J, Deutsch G K, Tallal P, Merzenich M M, Gabrieli J D
Institute of Neuroscience, Stanford University, CA 94305, USA.
Neuroreport. 2001 Feb 12;12(2):299-307. doi: 10.1097/00001756-200102120-00024.
Developmental dyslexia, characterized by difficulty in reading, has been associated with phonological and orthographic processing deficits. fMRI was performed on dyslexic and normal-reading children (8-12 years old) during phonological and orthographic tasks of rhyming and matching visually presented letter pairs. During letter rhyming, both normal and dyslexic reading children had activity in left frontal brain regions, whereas only normal-reading children had activity in left temporo-parietal cortex. During letter matching, normal-reading children showed activity throughout extrastriate cortex, especially in occipito-parietal regions, whereas dyslexic children had little activity in extrastriate cortex during this task. These results indicate dyslexia may be characterized in childhood by disruptions in the neural bases of both phonological and orthographic processes important for reading.
发育性阅读障碍以阅读困难为特征，与语音和正字法处理缺陷有关。对患有阅读障碍和正常阅读的儿童（8至12岁）在进行押韵和匹配视觉呈现字母对的语音和正字法任务时进行了功能磁共振成像（fMRI）。在字母押韵过程中，正常阅读和患有阅读障碍的儿童在左额叶脑区均有活动，而只有正常阅读的儿童在左颞顶叶皮层有活动。在字母匹配过程中，正常阅读的儿童在整个纹外皮层均有活动，尤其是在枕顶叶区域，而患有阅读障碍的儿童在此任务期间在纹外皮层几乎没有活动。这些结果表明，阅读障碍在儿童期可能表现为对阅读很重要的语音和正字法过程的神经基础受到破坏。
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