Backes Walter, Vuurman Eric, Wennekes Rianne, Spronk Patricia, Wuisman Mea, van Engelshoven Jos, Jolles Jelle
Department of Radiology, Maastricht University Hospital, Maastricht University, Maastricht, The Netherlands.
J Child Neurol. 2002 Dec;17(12):867-71. doi: 10.1177/08830738020170121601.
Brain activation differences of reading-related processes between dyslexic and normal reading children were localized with functional magnetic resonance imaging (MRI). The children performed tasks that varied in visuospatial, orthographic, phonologic, and semantic processing demands. Enhanced activation of the left extrastriate cortex was found during all tasks in the dyslexic group. During orthographic processing, dyslexic children predominantly showed activation in the right prefrontal cortex, as also occurred during the visuo-spatial task. Normal readers also showed activation in the left prefrontal cortex. Dyslexic readers showed less activation of both the temporal and the prefrontal cortex during phonologic processing. The results suggest that dyslexic readers fail to use brain areas that are normally specialized in language processing, but rather use areas that underlie visuospatial processing.
利用功能磁共振成像（MRI）对诵读困难儿童和正常阅读儿童在阅读相关过程中的大脑激活差异进行了定位。这些儿童执行了在视觉空间、正字法、语音和语义处理要求方面有所不同的任务。在诵读困难组的所有任务中，发现左侧纹外皮层的激活增强。在正字法处理过程中，诵读困难儿童主要在右侧前额叶皮层表现出激活，在视觉空间任务中也是如此。正常阅读者在左侧前额叶皮层也表现出激活。诵读困难读者在语音处理过程中颞叶和前额叶皮层的激活较少。结果表明，诵读困难读者未能使用通常专门用于语言处理的脑区，而是使用了视觉空间处理所依赖的脑区。
