Lishner M, Koren G
Hospital for Sick Children in Toronto.
Can Fam Physician. 2001 Jan;47:41-2.
I have an 8-weeks' pregnant patient who was diagnosed with stage III Hodgkin's disease last week. The oncologist suggests delaying chemotherapy until the second trimester. What are the effects of chemotherapy on a fetus after the first trimester? Where can I find reliable information on the subject?
Available data suggest that exposure to chemotherapy during the first trimester of pregnancy is associated with increased risk of major malformations. Exposure during the second and third trimesters does not result in major malformations, but could have nonteratogenic effects, such as low birth weight. The brain develops throughout pregnancy, and it could be affected later in pregnancy.
我有一位怀孕8周的患者，上周被诊断为III期霍奇金淋巴瘤。肿瘤学家建议将化疗推迟到孕中期。孕早期之后化疗对胎儿有哪些影响？我在哪里可以找到关于这个主题的可靠信息？
现有数据表明，孕期头三个月接触化疗与重大畸形风险增加有关。在孕中期和孕晚期接触化疗不会导致重大畸形，但可能会有非致畸性影响，如低出生体重。大脑在整个孕期都在发育，可能在孕期后期受到影响。
