Egan P C, Costanza M E, Dodion P, Egorin M J, Bachur N R
Cancer Treat Rep. 1985 Dec;69(12):1387-89.
Plasma and milk concentrations of doxorubicin (DOX) and cisplatin were measured after iv administration of these agents to a lactating patient with ovarian cancer. Cisplatin was undetectable in human milk. Milk concentrations of DOX often exceeded those detected in concomitant plasma samples. For DOX, the highest milk:plasma concentration ratio was 4.43:1 and was observed 24 hours after administration of the drug. The area under concentration versus time curve (AUC) for DOX was approximately the same in plasma and milk. Doxorubicinol was the major metabolite of DOX in plasma and in milk. The AUC for doxorubicinol was ten times higher in milk than in plasma. However, the total amount of anthracycline antibiotic delivered in the milk (maximum concentration of active anthracycline antibiotic: 0.24 mg/L) was negligible.
在给一名患有卵巢癌的哺乳期患者静脉注射阿霉素（DOX）和顺铂后，测定了血浆和乳汁中这两种药物的浓度。人乳中未检测到顺铂。阿霉素的乳汁浓度常常超过同期血浆样本中的浓度。对于阿霉素，最高的乳汁与血浆浓度比为4.43:1，在给药后24小时观察到该比值。阿霉素的浓度-时间曲线下面积（AUC）在血浆和乳汁中大致相同。阿霉素醇是血浆和乳汁中阿霉素的主要代谢产物。阿霉素醇的AUC在乳汁中比在血浆中高10倍。然而，乳汁中递送的蒽环类抗生素总量（活性蒽环类抗生素的最大浓度：0.24 mg/L）可忽略不计。
