Gupta U D, Katoch K, Singh H B, Natrajan M, Sharma V D, Katoch V M
Central JALMA Institute for Leprosy, Tajganj, Agra 282 001.
Indian J Lepr. 2000 Oct-Dec;72(4):437-42.
The therapeutic effect of a drug regimen of conventional drugs as well as newer drugs like ofloxacin and minocycline in smear-positive multibacillary (MB) leprosy cases was assessed by mouse foot-pad and ATP bioluminiscence methods. Biopsies were taken before starting treatment and after one year of treatment. They were processed for viability assessment by normal mouse foot-pad inoculation and bacillary ATP assay techniques. The test regimen was quite effective in its anti-bacterial effect as it was found to result in loss of bacillary viability in all the cases, as assessed by both methods.
通过小鼠足垫和ATP生物发光法评估了常规药物以及氧氟沙星和米诺环素等新药组成的药物方案对涂片阳性多菌型（MB）麻风病例的治疗效果。在开始治疗前和治疗一年后进行活检。通过正常小鼠足垫接种和细菌ATP检测技术对活检样本进行处理以评估其活力。通过两种方法评估发现，该测试方案在抗菌效果方面相当有效，因为在所有病例中均导致细菌活力丧失。
