Agoff S N, Folpe A L, Grieco V S, Garcia R L
Department of Cytopathology and Pathology, Harborview Medical Center and University of Washington Medical Center, Seattle, Washington, USA.
Acta Cytol. 2001 Jan-Feb;45(1):93-8. doi: 10.1159/000327195.
Spindle cell lipoma (SCL) is a benign neoplasm characterized by a mixture of mature fat, bland spindle cells and wiry collagen in a variably myxoid background. Oral SCLs are rare, and only four cases of intramuscular SCL exist in the literature. We report the first case of intramuscular SCL of the oral cavity with fine needle aspiration (FNA) findings.
A 61-year-old woman presented with a 3-cm mass in the right gingivobuccal sulcus. Papanicolaoustained FNA smears were hypocellular and contained loose collections of spindle cells in a myxoid background, numerous mast cells, rare capillary fragments and portions of skeletal muscle. The spindle cells had mild nuclear enlargement, focal nuclear irregularities, rare intranuclear inclusions and occasional small nucleoli. No lipoblasts or mitoses were identified. There was intermingling of the spindle cells with the skeletal muscle fragments.
Intraoral SCL is a rare lesion but should be considered in the differential for a benign spindle cell neoplasm in the oral cavity. Clues to diagnosis on cytology include mature fat, bland spindle cells, a myxoid background and mast cells.
梭形细胞脂肪瘤（SCL）是一种良性肿瘤，其特征是在不同程度的黏液样背景中混合有成熟脂肪、温和的梭形细胞和细的胶原纤维。口腔SCL罕见，文献中仅有4例肌内SCL的报道。我们报告首例口腔肌内SCL的细针穿刺抽吸（FNA）结果。
一名61岁女性，右侧牙龈颊沟有一个3厘米的肿物。巴氏染色的FNA涂片细胞成分少，在黏液样背景中有散在的梭形细胞、大量肥大细胞、罕见的毛细血管片段和部分骨骼肌。梭形细胞核轻度增大，有局灶性核不规则，罕见核内包涵体，偶见小核仁。未发现脂肪母细胞或有丝分裂象。梭形细胞与骨骼肌片段相互混杂。
口腔内SCL是一种罕见病变，但在鉴别口腔良性梭形细胞肿瘤时应予以考虑。细胞学诊断线索包括成熟脂肪、温和的梭形细胞、黏液样背景和肥大细胞。
