Birner A M, Meyer L P
Pharmacy Department, Darmouth-Hitchcock Medical Center, Lebanon, New Hampshire 03756, USA.
Pharmacotherapy. 2001 Feb;21(2):258-60. doi: 10.1592/phco.21.2.258.34108.
A woman newly diagnosed with colon cancer began chemotherapy with fluorouracil and leucovorin. Chemotherapy was given daily for 5 days with prochlorperazine premedication and was well tolerated. The patient continued her previous drug regimen during and after chemotherapy, which consisted of hormone replacement therapy, chloroquine, insulin, multivitamin, and tretinoin topical cream. Several days after the end of the first cycle of chemotherapy she experienced a dramatic photosensitivity reaction. Tretinoin application was discontinued, and she recovered. All other drugs remained unchanged. The patient was treated with five additional cycles of chemotherapy. She did not experience the reaction with any potentially photosensitizing agents again; only when the specific sequence and drug combination was administered in the first cycle.
一名新诊断为结肠癌的女性开始接受氟尿嘧啶和亚叶酸钙化疗。化疗连续5天每日进行，并使用氯丙嗪进行预处理，耐受性良好。患者在化疗期间及化疗后继续使用之前的药物治疗方案，包括激素替代疗法、氯喹、胰岛素、多种维生素和维甲酸外用乳膏。在第一个化疗周期结束几天后，她出现了严重的光敏反应。停用了维甲酸外用乳膏后，她康复了。所有其他药物保持不变。该患者又接受了五个周期的化疗。她再也没有与任何潜在的光敏剂发生反应；只有在第一个周期使用特定的药物顺序和组合时才出现过。
