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中枢神经细胞瘤:2例病例报告并文献复习

Central neurocytoma: 2 case reports and review of the literature.

作者信息

Dodero F, Alliez J R, Metellus P, Hassan H, Hassoun J, Alliez B

机构信息

Department of Neurosurgery, North Hospital, Marseille, France.

出版信息

Acta Neurochir (Wien). 2000;142(12):1417-22. doi: 10.1007/s007010070014.

Abstract

Central neurocytoma is a rare benign tumor of the central nervous system occuring in young adults and typically located in the ventricles. The tumor is composed of small round cells with neuronal differentiation and has a favourable prognosis. We report two cases of giant central neurocytomas with a triventricular extension in two young women. The first case concerned a 26 years old righthanded woman in whom an intraventricular mass was discovered, after a car accident with head trauma. Skull radiography showed an enlargment of the sella turcica. A CT scan performed in order to examine the pituitary gland revealed a voluminous and heterogenous intraventricular tumor with calcification. The second case concerned a 26 years old righthanded woman, presenting with a 4 Glasgow Coma Scale Score preceded by an acute onset of headache with projectile vomiting. A CT scan performed in emergency revealed a voluminous intraventricular mass with significant hydrocephalus. We review the different pathological and topographical patterns of previously published neurocytomas and discuss surgical management, effectiveness of radiation therapy and biological behavior.

摘要

中枢神经细胞瘤是一种罕见的中枢神经系统良性肿瘤,好发于年轻人,通常位于脑室。该肿瘤由具有神经元分化的小圆形细胞组成,预后良好。我们报告了两例年轻女性巨大中枢神经细胞瘤并累及三脑室的病例。第一例是一名26岁的右利手女性,在头部外伤的车祸后发现脑室内有肿物。颅骨X线片显示蝶鞍增大。为检查垂体而进行的CT扫描显示脑室内有一个体积大且不均匀的肿瘤,并伴有钙化。第二例是一名26岁的右利手女性,格拉斯哥昏迷评分为4分,之前有急性头痛伴喷射性呕吐。急诊进行的CT扫描显示有一个体积大的脑室内肿物并伴有明显脑积水。我们回顾了既往发表的神经细胞瘤的不同病理和部位模式,并讨论了手术治疗、放射治疗效果及生物学行为。

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