Pafumi C, Farina M, Pernicone G, Bandiera S, Russo A, Mangiafico L, Cianci A
University Department of Obstetrics and Gynaecology, S. Bambino Hospital, University of Catania, Italy.
Clin Exp Obstet Gynecol. 2000;27(3-4):185-7.
The health background management and outcome of five pregnancies in women affected by Cooley Disease are described and the preconceptual guidance and care are considered. The patients were selected from a group of 103 thalassemic women divided into three subgroups according to their first and successive menstruation characteristics. Only one woman needed induction of ovulation. A precise and detailed pre-pregnancy assessment was done before each conception. All the women were in labour at 38 weeks' gestation, and five healthy babies were born at term, weighing between 2,600 and 3,200 g. The improvement in current treatments will result in a continuous increase in pregnancies in thalassemic women, making pregnancy a real eventuality for them. Furthermore, we are studying the possibility of collecting foetus umbilical cord blood after delivery, with the aim of obtaining complete marrow reconstitution in an attempt at heterologous transplantation to the mother.
本文描述了患有库利氏病的女性五次妊娠的健康背景管理及结局，并探讨了孕前指导与护理。这些患者选自103名地中海贫血女性群体，根据她们首次及后续月经特征分为三个亚组。仅一名女性需要诱导排卵。每次受孕前均进行了精确且详细的孕前评估。所有女性均在妊娠38周时分娩，足月产下五名健康婴儿，体重在2600克至3200克之间。当前治疗方法的改进将使地中海贫血女性的妊娠持续增加，使妊娠成为她们切实可能面临的情况。此外，我们正在研究产后采集胎儿脐带血的可能性，旨在通过异基因移植给母亲来实现完全的骨髓重建。
