Mamede J A, Oliveira-Filho R M, Simo s M J, Mora O A, Espiridião SKulay L
Universidade de Mogi das Cruzes School of Medicine, Brazil.
Clin Exp Obstet Gynecol. 2000;27(3-4):227-30.
The antiviral effect of azidothymidine (AZT) can be potentiated by acyclovir (ACV), and this drug association has been used in the management of HIV-infected patients. In the present study we examined the effects of this association on the livers and kidneys of both pregnant rats and their concepts. Previous data from this laboratory suggested that the deleterious effects of ACV on rat pregnancy are due to its extraplacental actions and these are, at least in part, counteracted by concomitant treatment with AZT. Kidneys and livers of pregnant rats were noticed to be much more sensitive to the toxic action of the drugs than those of their concepts, ACV eliciting much more evident morphological alterations than did AZT. Contrary to what was expected, in the group of rats treated with both drugs AZT was not able to diminish the severity of the alterations evoked by ACV. The proposed "protective" action of AZT against the abortive effect of ACV on rat pregnancy does not seem to be exerted through a renal or hepatic pathway.
叠氮胸苷（AZT）的抗病毒作用可被阿昔洛韦（ACV）增强，这种药物联合已用于治疗HIV感染患者。在本研究中，我们研究了这种联合用药对妊娠大鼠及其胎儿肝脏和肾脏的影响。该实验室先前的数据表明，ACV对大鼠妊娠的有害作用是由于其胎盘外作用，而这些作用至少部分地被同时给予AZT所抵消。观察到妊娠大鼠的肾脏和肝脏对药物的毒性作用比其胎儿更敏感，ACV引起的形态学改变比AZT更明显。与预期相反，在同时使用两种药物治疗的大鼠组中，AZT并不能减轻ACV引起的改变的严重程度。AZT对ACV对大鼠妊娠流产作用的所谓“保护”作用似乎不是通过肾脏或肝脏途径发挥的。
