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核心技术专利：CN118964589B侵权必究

核心技术专利：CN118964589B侵权必究

Mamede J A, Simões M de J, Novo N F, Juliano Y, Oliveira-Filho R M, Kulay Júnior L

Department of Gynecology and Obstetrics, Escola Paulista de Medicina, São Paulo, Brazil.

Gen Pharmacol. 1995 May;26(3):523-6. doi: 10.1016/0306-3623(94)00237-h.

The antiviral effect of azidothymidine (AZT) can be potentiated by acyclovir (ACV), and this drug association has been used in the management of HIV-infected patients. In the present study we examined the effects of such an association on rat pregnancy. 2. AZT (60 mg/kg b.w.) and ACV (60 mg/kg b.w.) were given to groups of pregnant rats once a day from the 1st to the 20th day of gestation. 3. Maternal body weight gain was severely affected by ACV; this effect was attenuated in rats treated with AZT+ACV and was virtually absent with AZT alone. 4. The abortive action of ACV was markedly diminished in the group treated with the association AZT+ACV. 5. The deleterious effects of ACV on rat pregnancy are presumably due to its extraplacental actions, and these are, at least in part, counteracted by concomitant treatment with AZT.

阿昔洛韦（ACV）可增强齐多夫定（AZT）的抗病毒作用，这种药物联合已用于治疗HIV感染患者。在本研究中，我们研究了这种联合对大鼠妊娠的影响。2. 从妊娠第1天至第20天，每天给妊娠大鼠组给予AZT（60mg/kg体重）和ACV（60mg/kg体重）。3. ACV严重影响母体体重增加；在接受AZT+ACV治疗的大鼠中这种作用减弱，而单独使用AZT时几乎没有这种作用。4. 在接受AZT+ACV联合治疗的组中，ACV的流产作用明显减弱。5. ACV对大鼠妊娠的有害作用可能归因于其胎盘外作用，并且这些作用至少部分地被同时使用AZT所抵消。

Mamede J A, Simões M de J, Novo N F, Juliano Y, Oliveira-Filho R M, Kulay Júnior L

Department of Gynecology and Obstetrics, Escola Paulista de Medicina, São Paulo, Brazil.

Gen Pharmacol. 1995 May;26(3):523-6. doi: 10.1016/0306-3623(94)00237-h.

The antiviral effect of azidothymidine (AZT) can be potentiated by acyclovir (ACV), and this drug association has been used in the management of HIV-infected patients. In the present study we examined the effects of such an association on rat pregnancy. 2. AZT (60 mg/kg b.w.) and ACV (60 mg/kg b.w.) were given to groups of pregnant rats once a day from the 1st to the 20th day of gestation. 3. Maternal body weight gain was severely affected by ACV; this effect was attenuated in rats treated with AZT+ACV and was virtually absent with AZT alone. 4. The abortive action of ACV was markedly diminished in the group treated with the association AZT+ACV. 5. The deleterious effects of ACV on rat pregnancy are presumably due to its extraplacental actions, and these are, at least in part, counteracted by concomitant treatment with AZT.

阿昔洛韦（ACV）可增强齐多夫定（AZT）的抗病毒作用，这种药物联合已用于治疗HIV感染患者。在本研究中，我们研究了这种联合对大鼠妊娠的影响。2. 从妊娠第1天至第20天，每天给妊娠大鼠组给予AZT（60mg/kg体重）和ACV（60mg/kg体重）。3. ACV严重影响母体体重增加；在接受AZT+ACV治疗的大鼠中这种作用减弱，而单独使用AZT时几乎没有这种作用。4. 在接受AZT+ACV联合治疗的组中，ACV的流产作用明显减弱。5. ACV对大鼠妊娠的有害作用可能归因于其胎盘外作用，并且这些作用至少部分地被同时使用AZT所抵消。