Cao L, Zhou Y, Liu Z, Du Q, Li W, Hu Y, Li W
Family Planning Research Institute, Tongji Medical University, Wuhan 430030.
J Tongji Med Univ. 2000;20(3):249-52. doi: 10.1007/BF02887005.
Effects of two types of intrauterine device (IUD) on the prostaglandins and endothelin (ET) in uterus and on the endometrial morphology in rats and rabbits, and Cu2+ releasing amounts of both IUDs in vitro were observed. The results showed that the inhibiting action of the indomethacin-releasing copper IUD (FICu-IUD) on the PGI2 was stronger than that on the TXA2, the ratio of 6-keto-PGF1 alpha/TXB2 was reduced with the increase of the doses. There were significant differences between the groups. The FICu-IUD could inhibit the rising of the ET level and lighten the endometrial impairment caused by the FCu-IUD, and promote copper ion release. It was suggested that indomethacin released by FICu-IUD could effectively reduce abnormal uterine bleeding.
观察了两种宫内节育器（IUD）对大鼠和家兔子宫前列腺素、内皮素（ET）及子宫内膜形态的影响，以及两种IUD在体外的铜离子释放量。结果显示，含吲哚美辛铜宫内节育器（FICu-IUD）对前列环素（PGI2）的抑制作用强于对血栓素A2（TXA2）的抑制作用，随着剂量增加，6-酮-前列腺素F1α/血栓素B2（6-keto-PGF1α/TXB2）比值降低。组间差异有统计学意义。FICu-IUD可抑制ET水平升高，减轻FCu-IUD所致的子宫内膜损伤，并促进铜离子释放。提示FICu-IUD释放的吲哚美辛可有效减少子宫异常出血。
