Zhao G, Li M, Zhu P, Xu R, Wang J, Xu R
Pyong Yang Maternity Hospital, DPRK, Beijing, China.
Hum Reprod. 1997 Jul;12(7):1563-6. doi: 10.1093/humrep/12.7.1563.
The intrauterine device (IUD) is an effective method of birth control. However, IUD-induced uterine bleeding is a major side-effect and always causes inconvenience, sometimes even anaemia. It has been reported that oral administration of indomethacin could can reduce IUD-induced uterine bleeding. In the present study, we investigated whether indomethacin-releasing copper IUD (IR-Cu-IUD) can prevent insertion-induced uterine bleeding and its mechanism. Nine healthy volunteers of reproductive age were selected for the study. Endometrial tissues were collected at same menstrual stage prior to and 3-6 months after IR-Cu-IUD insertion. Endometrial morphology, cell proliferation/differentiation, morphometry and activity of complement Factor VIII were examined. No significant difference was found in any of the parameters examined in the same patients, both prior to and after IR-Cu-IUD insertion. By comparison with data previously obtained from the patients who had Cu-IUD insertions, it is clear that IR-Cu-IUD markedly reduced IUD-induced uterine bleeding and this reduction is primarily contributed by the anti-inflammatory action of indomethacin.
宫内节育器（IUD）是一种有效的避孕方法。然而，IUD引起的子宫出血是一个主要的副作用，总是会带来不便，有时甚至会导致贫血。据报道，口服吲哚美辛可以减少IUD引起的子宫出血。在本研究中，我们调查了释放吲哚美辛的铜宫内节育器（IR-Cu-IUD）是否能预防放置引起的子宫出血及其机制。选择9名健康育龄志愿者进行研究。在IR-Cu-IUD放置前和放置后3至6个月的相同月经阶段收集子宫内膜组织。检查子宫内膜形态、细胞增殖/分化、形态测量和补体因子VIII活性。在同一患者中，IR-Cu-IUD放置前后所检查的任何参数均未发现显著差异。与先前从放置铜宫内节育器的患者获得的数据相比，很明显IR-Cu-IUD显著减少了IUD引起的子宫出血，这种减少主要是由吲哚美辛的抗炎作用所致。
