Takekawa Y, Kimura M, Sakakibara M, Yoshii R, Shikata T
Department of Pathology, Yokosuka Municipal Hospital, Yokosuka 240-0195.
Rinsho Byori. 2001 Jan;49(1):66-70.
Normal-sized ovary carcinoma syndrome(NOCS) is characterized by diffuse metastatic malignant disease of the abdominal cavity in females, with normal-sized ovaries, and no origin assigned definitively by intraoperative evaluation. To elucidate the characteristics of NOCS arising from ovarian carcinoma, we investigated the immunohistochemical reactivities of keratin, epithelial membrane antigen(EMA), vimentin, and proliferative cell nuclear antigen(PCNA) in 4 cases of ovarian carcinoma with NOCS(NOCS group), including 3 cases of serous surface papillary adenocarcinoma(SSPC) and 1 case of small ovarian primary serous papillary adenocarcinoma(SPC). These cases were compared with 3 cases of ovarian carcinoma without NOCS(non-NOCS group), including 3 cases of SPC. Cytological and histological testing of the NOCS and non-NOCS groups showed the same findings. Similar reactivities for keratin, EMA and vimentin were observed in the NOCS and non-NOCS groups. No significant change of PCNA labeling index between the groups was seen. However, clinical stage of the NOCS group was higher than that of non-NOCS group. It was hypothesized that exposure of cancer cells to peritoneal cavity in ovarian SSPC leads to the spread. In NOCS case arising from small-sized ovarian carcinoma, another factor was thought to be involved, such as genetic alteration, but it is not known.
正常大小卵巢癌综合征（NOCS）的特征为女性腹腔内弥漫性转移性恶性疾病，卵巢大小正常，且术中评估无法明确其起源。为阐明卵巢癌所致NOCS的特征，我们研究了4例伴有NOCS的卵巢癌（NOCS组）中角蛋白、上皮膜抗原（EMA）、波形蛋白和增殖细胞核抗原（PCNA）的免疫组化反应性，其中包括3例浆液性表面乳头状腺癌（SSPC）和1例小卵巢原发性浆液性乳头状腺癌（SPC）。将这些病例与3例不伴有NOCS的卵巢癌（非NOCS组）进行比较，后者包括3例SPC。NOCS组和非NOCS组的细胞学和组织学检查结果相同。在NOCS组和非NOCS组中观察到角蛋白、EMA和波形蛋白的反应性相似。两组之间PCNA标记指数未见显著变化。然而，NOCS组的临床分期高于非NOCS组。据推测，卵巢SSPC中的癌细胞暴露于腹腔会导致扩散。在由小尺寸卵巢癌引起的NOCS病例中，认为还涉及另一个因素，如基因改变，但尚不清楚。
