Tattan T M, Creed F H
University of Manchester School of Psychiatry and Behavioural Sciences, England.
Schizophr Bull. 2001;27(1):149-55. doi: 10.1093/oxfordjournals.schbul.a006853.
Poor compliance with medication has been reported in up to 40 percent of outpatients with schizophrenia. This study examines the relationship between compliance with depot neuroleptic medication and severity of negative symptoms of schizophrenia. Compliance with depot neuroleptic medication during the preceding year was calculated for 64 patients with a DSM-III-R diagnosis of schizophrenia. The severity of negative symptoms was assessed using the Scale for the Assessment of Negative Symptoms (SANS). Patients who complied poorly with medication had significantly greater severity of negative symptoms of schizophrenia, especially avolition, apathy, and alogia. Duration of illness and duration of prescribed medication were independently associated with compliance, but no other features were associated in the multiple regression model. These findings suggest that negative symptoms are one of the factors of importance in determining whether a patient will attend for depot neuroleptic medication.
据报道，高达40%的精神分裂症门诊患者存在药物依从性差的问题。本研究探讨长效抗精神病药物依从性与精神分裂症阴性症状严重程度之间的关系。对64例符合DSM-III-R精神分裂症诊断标准的患者计算其前一年长效抗精神病药物的依从性。使用阴性症状评定量表（SANS）评估阴性症状的严重程度。药物依从性差的患者精神分裂症阴性症状明显更严重，尤其是意志缺乏、情感淡漠和言语减少。病程和规定用药时间与依从性独立相关，但在多元回归模型中没有其他特征与之相关。这些发现表明，阴性症状是决定患者是否接受长效抗精神病药物治疗的重要因素之一。
