Müller M J, Szegedi A, Wetzel H, Benkert O
Department of Psychiatry, University of Mainz, Germany.
Schizophr Bull. 2001;27(1):19-28. doi: 10.1093/oxfordjournals.schbul.a006856.
Relationships among different symptom domains were investigated in patients with acute exacerbation of schizophrenia with depressive symptoms, psychotic depression, or schizoaffective disorder, depressive subtype. Scores for depression and depressive factors were correlated with positive, negative, and extrapyramidal symptoms within diagnostic categories. No between-group differences in the relationship of different symptom domains could be found, and no substantial relationship between depression and positive symptoms could be revealed in any diagnostic subgroup. Only the retardation factor of depression showed a significant overlap with negative symptoms; depressive core symptoms did not. Core symptoms of depression were independent from other symptoms in all investigated diagnostic groups. Depression seems to represent a heterogeneous symptom domain with unique relationships of components to positive and negative symptoms across nosological borders. A more differentiated assessment, analysis, and treatment of depressive symptoms is therefore recommended for patients with combined depressive and psychotic symptoms.
在伴有抑郁症状的精神分裂症急性加重患者、精神病性抑郁症患者或分裂情感性障碍（抑郁亚型）患者中，研究了不同症状领域之间的关系。在诊断类别中，抑郁和抑郁因子得分与阳性、阴性及锥体外系症状相关。未发现不同症状领域关系的组间差异，且在任何诊断亚组中均未揭示抑郁与阳性症状之间存在实质性关系。仅抑郁的迟缓因子与阴性症状有显著重叠；抑郁核心症状则不然。在所有研究的诊断组中，抑郁核心症状与其他症状无关。抑郁似乎代表了一个异质性症状领域，其各组成部分与不同疾病分类中的阳性和阴性症状有着独特的关系。因此，对于合并抑郁和精神病性症状的患者，建议对抑郁症状进行更具区分性的评估、分析和治疗。
