Pahwa R, Lyons K E, Wilkinson S B, Tröster A I, Overman J, Kieltyka J, Koller W C
Department of Neurology, University of Kansas Medical Center, Kansas City 66160, USA.
Mov Disord. 2001 Jan;16(1):140-3. doi: 10.1002/1531-8257(200101)16:1<140::aid-mds1025>3.0.co;2-t.
To compare outcome in Essential Tremor (ET) patients who have undergone either thalamotomy or Deep Brain Stimulation (DBS) of the thalamus.
Although both thalamotomy and thalamic DBS are effective surgical treatments of tremor, it is not known if one procedure is superior to the other.
DESIGN/METHODS: Thirty-five ET patients underwent thalamotomy between 1994-1998. Data on 18 patients were excluded. The remaining 17 patients were matched for age, sex, side of surgery, and tremor severity to 17 ET patients who underwent thalamic DBS. There were nine men and eight women in each group. The mean age of the thalamotomy group was 74.4 years and that of the thalamic DBS group was 73.1 years.
There were no significant differences between any efficacy outcome variables comparing thalamotomy to DBS of the thalamus at baseline or follow-up visits. The surgical complications were higher for the thalamotomy group as compared to the DBS group. However, a larger number of DBS patients underwent repeat surgeries due to problems with the device and the leads.
Although the efficacy is similar for thalamotomy and DBS of the thalamus for ET, thalamotomy is associated with a higher complication rate. DBS of the thalamus should be the procedure of choice for the surgical treatment of ET in most cases.
比较接受丘脑切开术或丘脑深部脑刺激术（DBS）的特发性震颤（ET）患者的治疗结果。
尽管丘脑切开术和丘脑DBS都是治疗震颤的有效外科手术，但尚不清楚哪种手术更具优势。
设计/方法：1994年至1998年间，35例ET患者接受了丘脑切开术。排除了18例患者的数据。其余17例患者在年龄、性别、手术侧和震颤严重程度方面与17例接受丘脑DBS的ET患者进行匹配。每组有9名男性和8名女性。丘脑切开术组的平均年龄为74.4岁，丘脑DBS组的平均年龄为73.1岁。
在基线或随访时，比较丘脑切开术和丘脑DBS的任何疗效结果变量均无显著差异。与DBS组相比，丘脑切开术组的手术并发症更高。然而，由于设备和导线问题，更多的DBS患者接受了重复手术。
尽管丘脑切开术和丘脑DBS治疗ET的疗效相似，但丘脑切开术的并发症发生率更高。在大多数情况下，丘脑DBS应作为ET手术治疗的首选方法。
