Herold C, Berg P, Kupfal D, Becker D, Schuppan D, Hahn E G, Schneider H T
Dig Dis Sci. 2000 Nov;45(11):2233-7. doi: 10.1023/a:1026600921967.
Our aim was to compare color-coded Doppler sonography (CCDS) and quantitative testing of liver function (QTLF) in patients with chronic hepatitis C. In all, 74 patients with chronic hepatitis C and mild fibrosis underwent QTLF, which included aminopyrine breath test (ABT), galactose elimination capacity (GEC), sorbitol clearance (SC), and indocyanine green clearance (ICG). Hepatic artery velocity and resistance index (HA-V, HA-RI) as well as portal vein velocity (PV-V) were measured by CCDS. ABT, GEC, and PV-V were significantly reduced, whereas SC1, ICG, HA-V, and HA-RI showed normal levels. There was a significant correlation between reduction in PV-V only with GEC and ABT. QTLF did not correlate with HA-V and HA-RI. In conclusion, in hepatitis C patients with liver fibrosis, ABT and GEC are decreased significantly, which was paralleled by a reduction of PV-V. Unexpectedly SC1 and ICG, the classical hepatic perfusion parameters, do not correlate with the parameters measured by CCDS.
我们的目的是比较慢性丙型肝炎患者的彩色编码多普勒超声检查（CCDS）和肝功能定量检测（QTLF）。总共74例慢性丙型肝炎伴轻度纤维化患者接受了QTLF，其中包括氨基比林呼气试验（ABT）、半乳糖清除能力（GEC）、山梨醇清除率（SC）和吲哚菁绿清除率（ICG）。通过CCDS测量肝动脉速度和阻力指数（HA-V，HA-RI）以及门静脉速度（PV-V）。ABT、GEC和PV-V显著降低，而SC1、ICG、HA-V和HA-RI显示正常水平。仅PV-V降低与GEC和ABT之间存在显著相关性。QTLF与HA-V和HA-RI不相关。总之，在伴有肝纤维化的丙型肝炎患者中，ABT和GEC显著降低，同时PV-V也降低。出乎意料的是，经典的肝灌注参数SC1和ICG与CCDS测量的参数不相关。
