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逆流色谱法和离心分配色谱法中的对映体拆分

Enantioseparations in counter-current chromatography and centrifugal partition chromatography.

作者信息

Foucault A P

机构信息

URM2-CNRS UMR 7540, Lab. VP/BM, IFREMER, Nantes, France.

出版信息

J Chromatogr A. 2001 Jan 12;906(1-2):365-78. doi: 10.1016/s0021-9673(00)00499-4.

DOI:10.1016/s0021-9673(00)00499-4
PMID:11215897
Abstract

Examples of chiral separations in counter-current chromatography (CCC) and centrifugal partition chromatography (CPC) are not numerous, due to the difficulty of finding chiral selectors highly selective in the liquid phase as well as a combination of solvents that does not destroy the selectivity and retains the capacity to elute chiral isomers of interest. New ideas and new chiral selectors generally come from other separation techniques, as will be highlighted in this review.

摘要

由于难以找到在液相中具有高选择性的手性选择剂以及不会破坏选择性且保留洗脱目标手性异构体能力的溶剂组合，逆流色谱（CCC）和离心分配色谱（CPC）中的手性分离实例并不多。新的思路和新的手性选择剂通常来自其他分离技术，本综述将重点介绍这一点。

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