Magnenat G, Felber J P, Curchod B, Gomez F, Pittet P, Bonjour J P, Weissbrodt P, Geser C A, Muller-Hess R, Jéquier E
Schweiz Med Wochenschr. 1975 Jan 18;105(3):69-73.
The use of continuous indirect calorimetry in the course of a 100 g OGTT in 10 normal subjects has shown that carbohydrate oxidation rises with the secondary fall in blood glucose, suggesting that it could result from glucose stored under the influence of insulin. The experimental increase in FFA by a neutral fat infusion in 8 normal subjects decreased this oxidation in spite of the insulin rise. In a group of 5 non-obese, non-ketotic insulin-deficient diabetics, carbohydrate oxidation was found to be normal and directly correlated with plasma glucose levels. On the other hand, in 7 obese diabetics with high plasma insulin levels carbohydrate oxidation was found to be low, suggesting that carbohydrate intolerance could result from the non-oxidation of glucose. This study shows heterogeneity of diabetes, since glucose intolerance could result from non-oxidation of glucose as well as from insufficient pancreatic secretion.
对10名正常受试者进行100克口服葡萄糖耐量试验（OGTT）期间使用连续间接测热法，结果显示碳水化合物氧化随着血糖的继发性下降而增加，这表明其可能是由胰岛素作用下储存的葡萄糖所致。在8名正常受试者中通过输注中性脂肪使游离脂肪酸（FFA）实验性增加，尽管胰岛素水平升高，但碳水化合物氧化仍降低。在一组5名非肥胖、非酮症胰岛素缺乏型糖尿病患者中，发现碳水化合物氧化正常且与血浆葡萄糖水平直接相关。另一方面，在7名血浆胰岛素水平高的肥胖糖尿病患者中，发现碳水化合物氧化较低，这表明碳水化合物不耐受可能是由葡萄糖未氧化所致。这项研究表明糖尿病具有异质性，因为葡萄糖不耐受可能是由葡萄糖未氧化以及胰腺分泌不足所致。
