Meyer H U, Iselin H U, Curchod B, Rousselle J, Pahud P, Jéquier E, Felber J P
Schweiz Med Wochenschr. 1979 Dec 1;109(46):1811-3.
Indirect calorimetric studies were performed during a 100 g oral glucose tolerance test in diabetic patients with varying degrees of endocrine pancreatic dysfunction and in a control group of normal subjects. In 3 obese diabetics the study was repeated after a 3 day protein sparing modiefied fast. In diabetic patients the results show alterations of oxidation and storage of carbohydrates, related to insulin secretion deficiency on the one hand, and to overweight on the other. Endocrine pancreatic insufficiency may account directly for alterations observed in individuals with decreased or absent insulin response to glucose load, wheras metabolic factors such as adipose mass, hepatic steatosis, and peripheral insulin resistance appear to be responsible for alterations in carbohydrate oxidation and storage in subjects with relative endocrine pancreatic insufficiency, particularly obese diabetics.
在口服100克葡萄糖耐量试验期间，对不同程度内分泌性胰腺功能障碍的糖尿病患者以及正常受试者对照组进行了间接热量测定研究。对3名肥胖糖尿病患者在进行为期3天的保留蛋白质改良禁食后重复了该研究。在糖尿病患者中，结果显示碳水化合物氧化和储存的改变，一方面与胰岛素分泌不足有关，另一方面与超重有关。内分泌性胰腺功能不全可能直接导致对葡萄糖负荷胰岛素反应降低或缺乏的个体出现所观察到的改变，而诸如脂肪量、肝脂肪变性和外周胰岛素抵抗等代谢因素似乎是导致相对内分泌性胰腺功能不全的受试者（尤其是肥胖糖尿病患者）碳水化合物氧化和储存改变的原因。
