Jaing T H, Hsueh C, Tain Y L, Hung I J, Hsia S H, Kao C C
Department of Medicine, Chang Gung Children's Hospital, Taoyuan, Taiwan.
J Pediatr Hematol Oncol. 2001 Feb;23(2):142-4. doi: 10.1097/00043426-200102000-00016.
Langerhans cell histiocytosis (LCH) is an enigmatic disease usually occurring in children. Tumor lysis syndrome (TLS) is a clinical syndrome associated with severe metabolic derangement and oliguric acute renal failure. In this report, we present the clinical course of an infant with advanced LCH who had TLS develop after chemotherapy. Treatment with continuous arteriovenous hemofiltration resulted in effective control of serum uric acid, potassium, creatinine, phosphorus, and blood urea nitrogen levels in the blood.
