大麻素CB1介导对大鼠应激性胃溃疡的抑制作用。
Cannabinoid CB1-mediated inhibition of stress-induced gastric ulcers in rats.
作者信息
Germanò M P, D'Angelo V, Mondello M R, Pergolizzi S, Capasso F, Capasso R, Izzo A A, Mascolo N, De Pasquale R
机构信息
Pharmaco-Biological Department, School of Pharmacy, University of Messina, Italy.
出版信息
Naunyn Schmiedebergs Arch Pharmacol. 2001 Feb;363(2):241-4. doi: 10.1007/s002100000360.
The effect of cannabinoid drugs (i.p.) on cold/restraint stress-induced gastric ulcers was studied in rats. The cannabinoid receptor agonist (WIN 55,212-2, 0.1-1 mg/kg), but not the less active isomer WIN 55,212-3 (1 mg/kg), reduced gastric ulceration. The protective effect of WIN 55,212-2 (1 mg/kg) was counteracted by the cannabinoid CB1 receptor antagonist SR141716A, but not by the cannabinoid CB2 receptor antagonist SR144528. These results indicate that the antiulcer effect of the cannabinoid receptor agonist WIN 55,212-2 is mediated by cannabinoid CB1 receptors.
研究了大麻素类药物（腹腔注射）对大鼠冷/束缚应激诱导的胃溃疡的影响。大麻素受体激动剂（WIN 55,212-2，0.1-1毫克/千克）可减轻胃溃疡，而活性较低的异构体WIN 55,212-3（1毫克/千克）则无此作用。WIN 55,212-2（1毫克/千克）的保护作用被大麻素CB1受体拮抗剂SR141716A抵消，但未被大麻素CB2受体拮抗剂SR144528抵消。这些结果表明，大麻素受体激动剂WIN 55,212-2的抗溃疡作用是由大麻素CB1受体介导的。
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