Ellepola A N, Samaranayake L P
Department of Oral Medicine & Periodontology, Faculty of Dental Sciences, University of Peradeniya, Sri Lanka.
Dent Update. 2000 Apr;27(3):111-2, 114-6. doi: 10.12968/denu.2000.27.3.111.
The advent of the human immunodeficiency virus and the increasing prevalence of immunocompromised individuals in the community have resulted in a resurgence of opportunistic infections, including oral candidoses. Despite the availability of a number of effective antimycotics for the management of oral candidoses, therapeutic failure is not uncommon. Further, the presence of many clinical variants of oral candidosis, both new and old, may confound the unwary clinician and complicate its management. These problems have been partly circumvented by the introduction of the triazole group of antimycotics, which initially appeared to be highly effective. However, an alarming increase in organisms resistant to triazoles has been reported recently. In this paper we provide an overview of clinical variants of oral candidosis. A second paper will discuss recent advances in the usage of antimycotics in the management of this condition.
人类免疫缺陷病毒的出现以及社区中免疫功能低下个体的日益增多，导致包括口腔念珠菌病在内的机会性感染再度流行。尽管有多种有效的抗真菌药物可用于治疗口腔念珠菌病，但治疗失败的情况并不罕见。此外，口腔念珠菌病存在许多新的和旧的临床变体，这可能会使粗心的临床医生感到困惑，并使其管理复杂化。三唑类抗真菌药物的引入在一定程度上规避了这些问题，这类药物最初似乎非常有效。然而，最近有报道称对三唑类耐药的微生物数量惊人地增加。在本文中，我们对口腔念珠菌病的临床变体进行了概述。第二篇论文将讨论抗真菌药物在治疗这种疾病方面的最新进展。
