Mangano R M
Clinical Research & Development, Wyeth-Ayerst Research, Radnor, Pennsylvania, USA.
Int J Clin Pract Suppl. 2001 Jan(116):9-13.
Zaleplon is a non-benzodiazepine sleep medication that shows efficacy as a sleep inducer comparable to that of other hypnotics but with significantly fewer residual effects. In addition, evaluations of psychomotor or memory function at zaleplon peak plasma levels show much less impairment than noted with other hypnotics, suggesting an improved benefit-to-risk profile for zaleplon compared with older available agents. Thus, zaleplon can be used to treat symptoms of insomnia when they occur without the concern of next-day psychomotor or memory impairment, whether administered at bedtime or later during the night. Such an approach permits physicians to reformulate their strategies for safe and effective management of sleeplessness.
扎来普隆是一种非苯二氮䓬类睡眠药物，作为一种睡眠诱导剂，其疗效与其他催眠药相当，但残留效应明显较少。此外，在扎来普隆血浆浓度达到峰值时对精神运动或记忆功能进行评估，结果显示其损害程度远低于其他催眠药，这表明与现有的老药相比，扎来普隆的效益风险比有所改善。因此，当失眠症状出现时，无论在就寝时或夜间晚些时候给药，使用扎来普隆均可治疗失眠症状，而无需担心次日出现精神运动或记忆损害。这种方法使医生能够重新制定安全有效的失眠管理策略。
