Christensen R, Jensen U B, Jensen T G
Institute of Human Genetics, University of Aarhus, Denmark.
Histochem Cell Biol. 2001 Jan;115(1):73-82. doi: 10.1007/s004180000210.
In this paper we review various strategies for gene transfer into the skin, their applications and show some of our own examples. The skin is the most accessible somatic tissue. Inherited skin diseases, such as epidermolysis bullosa and ichthyosis, and various systemic metabolic disorders are under investigation as potential candidate diseases for cutaneous gene transfer. Research is directed against genetic therapy of wounds and malignancies as well. So far, cutaneous gene transfer only has been used experimentally, but several clinical trials are under preparation.
在本文中，我们综述了将基因导入皮肤的各种策略、它们的应用，并展示了我们自己的一些实例。皮肤是最易接近的体细胞组织。遗传性皮肤病，如大疱性表皮松解症和鱼鳞病，以及各种全身性代谢紊乱疾病，正作为皮肤基因转移的潜在候选疾病进行研究。研究也针对伤口和恶性肿瘤的基因治疗。到目前为止，皮肤基因转移仅用于实验，但有几项临床试验正在筹备中。
