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母亲的TORCH感染作为新生儿发病的一个原因

[TORCH infections in mothers as a cause of neonatal morbidity].

作者信息

Mladina N, Mehikić G, Pasić A

机构信息

Klinika za djecije bolesti, UKC Tuzla.

出版信息

Med Arh. 2000;54(5-6):273-6.

Abstract

When possible, diseases by expectant mothers and newborns, like long-term disabilities also, should be prevented by establishing early diagnoses, evaluation and implementation adequate therapy. The major goal of medical care is prevention of disorders with provision of adequate prenatal care for the expectant mother and precautions regarding the exposure to teratogenic infections. The range of pathological conditions produced by infections agents is wide, and the difference between maternal and fetal effects caused by any one agent is also important. Some maternal infections, especially during the early gestation, can result in fetal loss or malformation because the ability of the fetus to resist infectious organisms is limited and the fetal immunologic system is unable to prevent the disemination of infectious organisms to the various tissues. These infections are responsible for significant congenital neonatal morbidity as for as compromises a child's quality of life and infertility and sterility. One group of microbial agents--generally known as TORCH infections can cause remarkably similar manifestations, and is uncommon to test all when a prenatal infection is suspected. We analysed the practice of TORCH analyses with our patients and their mothers during last year (1999th) at the Pediatric Clinic and Clinic of Gynecology and Obstetrition-UCC Tuzla. At this time there were 5.028 deliveries. Out of short figure 544 or 10.8% newborns were early born and 245 or 4.8% were hypotrophic and 62 were still-born or 12.3 from 1000 deliveries. TORCH infection was analysed only in few cases. In the same period there were 3.457 children treated at the Pediatric Clinic in Tuzla. Only in 20 cases or 0.58% TORCH was made. Three or 15% were with remarkable sequeles like microcephaly, cerebrospinal liquid abnormality, seizures, hepatomegaly, cirrosis etc. TORCH analysis was made with all mothers. Only one was serologic CMV positive and we started with the therapy. History of four mothers or 20% have data about spontaneous abortions, and in other four or 20% we found data about early deliveries. The prevention of conatal infections was not made by any one. In our small group we made TORCH because of evident problems that were suspected of conatal infections. We concluded that there is a big risk of untreated maternal infections with women in fertile age in Bosnia and Herzegovina. This problem is not enough present in our medical practice.

摘要

只要有可能,就应通过早期诊断、评估和实施适当治疗来预防准妈妈和新生儿的疾病,以及像长期残疾这类情况。医疗护理的主要目标是预防疾病,为准妈妈提供充分的产前护理,并采取预防措施防止接触致畸感染源。感染病原体所引发的病理状况范围很广,任何一种病原体对母体和胎儿造成的影响差异也很重要。一些母体感染,尤其是在妊娠早期,可能导致胎儿流产或畸形,因为胎儿抵抗感染性生物体的能力有限,且胎儿免疫系统无法阻止感染性生物体扩散到各个组织。这些感染会导致严重的先天性新生儿发病,进而影响儿童的生活质量以及导致不孕不育。有一类微生物病原体——通常被称为TORCH感染——可引发非常相似的症状,当怀疑产前感染时,对所有病原体进行检测的情况并不常见。我们分析了去年(1999年)在图兹拉大学临床中心儿科诊所以及妇产科诊所,针对我们的患者及其母亲进行TORCH检测的情况。当时共有5028例分娩。在这些简略数据中,544例新生儿早产,占10.8%;245例发育不良,占4.8%;62例死产,即每1000例分娩中有12.3例。仅对少数病例进行了TORCH感染分析。同期,图兹拉儿科诊所治疗了3457名儿童。仅20例进行了TORCH检测,占0.58%。其中3例(占15%)有明显后遗症,如小头畸形、脑脊液异常、癫痫发作、肝肿大、肝硬化等。对所有母亲都进行了TORCH检测。只有一名母亲血清学巨细胞病毒呈阳性,我们对其展开了治疗。四名母亲(占20%)有自然流产史,另外四名母亲(占20%)有早产史。没有人采取预防先天性感染的措施。在我们这个小群体中,由于怀疑存在先天性感染的明显问题,才进行了TORCH检测。我们得出结论,在波斯尼亚和黑塞哥维那,育龄妇女的母体感染若未得到治疗,存在很大风险。这个问题在我们的医疗实践中并未得到充分重视。

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