新生儿TORCH感染的血清学检查结果与临床表现分析
[Analysis of serological findings and clinical manifestations of TORCH infections in newborns].
作者信息
Wang Lei, Li Ke-hua, Liu Hong, Liu Jing-yuan, Li Yun-juan
机构信息
ICU, Beijing Childrens Hospital Affiliated to Capital University of Medical Sciences, Beijing 100045, China.
出版信息
Zhonghua Shi Yan He Lin Chuang Bing Du Xue Za Zhi. 2003 Sep;17(3):283-4.
BACKGROUND
To search for the serological findings and early clinical manifestations as evidences for prevention and treatment TORCH infections in pregnant women and newborns as early as possible.
METHODS
ELASA was performed to screen specific anti-TORCH (Toxoplasma gondii, Cytomegalovirus, Rubella virus, Herpes simplex virus) Ig-M antibodies.
RESULTS
Totally 1,554 in-patients who were treated in Neonatal Intensive Care Unit (NICU) of our hospital from January 2000 to January 2003 were retrospectively studied, 48 of them had TORCH infections. Cytomegalovirus (CMV), rubella and herpes simplex virus infections accounted for 52.1%, 33.3% and 14.6%, respectively. None of them had toxoplasma infection.
CONCLUSION
TORCH infections can cause multiorgan lesions, such as hearing impairment, hyperbilirubinemias and liver dysfunction, impairment of neurologic system, myocardial impairment, thrombocytopenia, and congenital heart disease.Rubella vaccine inoculation, serological screening during pregnancy and early period of newborn, intervention and treatment in the early period are most important.
背景
寻找血清学检查结果及早期临床表现，以便尽早为预防和治疗孕妇及新生儿TORCH感染提供依据。
方法
采用酶联免疫吸附试验（ELASA）筛查特异性抗TORCH（弓形虫、巨细胞病毒、风疹病毒、单纯疱疹病毒）Ig-M抗体。
结果
回顾性研究2000年1月至2003年1月在我院新生儿重症监护病房（NICU）治疗的1554例住院患儿，其中48例发生TORCH感染。巨细胞病毒（CMV）、风疹和单纯疱疹病毒感染分别占52.1%、33.3%和14.6%。无一例发生弓形虫感染。
结论
TORCH感染可导致多器官损害，如听力障碍、高胆红素血症和肝功能障碍、神经系统损害、心肌损害、血小板减少及先天性心脏病。接种风疹疫苗、孕期及新生儿早期进行血清学筛查、早期干预和治疗至关重要。
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