van Deurs B, Röpke C
Anat Rec. 1975 Mar;181(3):659-77. doi: 10.1002/ar.1091810308.
The postnatal development of high-endothelial venules (HE-venules) in popliteal lymph nodes of normal and athymic mice was studied by light and electron microscopy. In the normal mice, undifferentiated postcapillary HEvenules are already present at birth. During the first four days after birth, ribosomes and mitochondria in the endothelial cells of the venules become more numerous, and the endoplasmic reticulum and in particular the Golgi complexes enlarge. At day four lymphocyte diapedesis through the venules becomes apparent. From the tenth day the HEvenules are structurally mature. However, diapedesis activity still increases till about a month postnatally. In mice with congenital aplasia of the thymus (nude mice) and in neonatally thymectomized mice the development of the HEvenules is similar to that in normal mice. In the athymic mice both lymphocytes and granulocytes migrate through the walls of the HEvenules. However, the blood level of lymphocytes in these mice is far below the value in normal mice. It is concluded that the development of the HEvenules during the first month of life is independent of the blood level of lymphocytes.
通过光学显微镜和电子显微镜研究了正常小鼠和无胸腺小鼠腘淋巴结中高内皮微静脉（HE微静脉）的出生后发育情况。在正常小鼠中，出生时就已存在未分化的毛细血管后HE微静脉。出生后的头四天，微静脉内皮细胞中的核糖体和线粒体数量增多，内质网尤其是高尔基体增大。在第四天，淋巴细胞通过微静脉的渗出变得明显。从第十天起，HE微静脉在结构上成熟。然而，渗出活性在出生后约一个月内仍会增加。在先天性胸腺发育不全的小鼠（裸鼠）和新生期胸腺切除的小鼠中，HE微静脉的发育与正常小鼠相似。在无胸腺小鼠中，淋巴细胞和粒细胞都通过HE微静脉壁迁移。然而，这些小鼠的淋巴细胞血水平远低于正常小鼠的值。得出的结论是，生命第一个月期间HE微静脉的发育与淋巴细胞的血水平无关。
