曲伐沙星的人体胎盘离体转运
Ex vivo human placental transfer of trovafloxacin.
作者信息
Casey B, Bawdon R E
机构信息
Department of Obstetrics and Gynecology, University of Texas Southwestern Medical Center, Dallas 75390-9032, USA.
出版信息
Infect Dis Obstet Gynecol. 2000;8(5-6):228-9. doi: 10.1155/S1064744900000326.
OBJECTIVE
The purpose of this study was to determine the ex vivo human placental transfer of trovafloxacin from the maternal circulation to the fetal circulation.
METHODS
Six placentas from uncomplicated, term, vaginal or cesarean deliveries were studied using the ex vivo isolated cotyledon perfusion chamber; 14C-antipyrine was used as a reference compound to determine the clearance index (CI) of trovafloxacin.
RESULTS
The CI of trovafloxacin was 0.19 +/- 0.13 at a mean trough concentration of 1.38 +/- 0.22 microg/ml and 0.16 +/- 0.10 at a mean peak concentration of 7.48 +/- 2.3 microg/ml as determined by our newly developed high-pressure liquid chromatographic assay. Tissue concentration did not exceed maternal concentration, and there was little or no accumulation when the perfusion system was closed for 1 hr.
CONCLUSIONS
Trovafloxacin crosses the placenta by simple diffusion and does not accumulate in the media to any extent, nor does it bind to tissue or accumulate in the placenta.
目的
本研究旨在确定曲伐沙星在体外从母体循环到胎儿循环的人胎盘转运情况。
方法
使用体外分离的子叶灌注室对6例来自无并发症足月阴道分娩或剖宫产的胎盘进行研究；以14C-安替比林作为参考化合物来测定曲伐沙星的清除指数（CI）。
结果
通过我们新开发的高压液相色谱分析法测定，曲伐沙星在平均谷浓度为1.38±0.22微克/毫升时的CI为0.19±0.13，在平均峰浓度为7.48±2.3微克/毫升时的CI为0.16±0.10。组织浓度未超过母体浓度，当灌注系统封闭1小时时，几乎没有或没有蓄积。
结论
曲伐沙星通过简单扩散穿过胎盘，在介质中不会有任何程度的蓄积，也不与组织结合或在胎盘中蓄积。
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