Hashimoto T, Tada T, Nakazato F, Maruyama T, Katai S, Izumi Y, Yamada Y, Ikeda S
Department of Medicine (Neurology), Shinshu University School of Medicine, Matsumoto, Japan.
Ann Neurol. 2001 Feb;49(2):242-5. doi: 10.1002/1531-8249(20010201)49:2<242::aid-ana44>3.0.co;2-g.
Pallidotomy was performed in a parkinsonian patient with off-period foot dystonia. Dystonia appeared at the beginning of surgery and disappeared after the first microelectrode penetration of the globus pallidus, perhaps a micropallidotomy effect. Neuronal recording during dystonia revealed that the mean firing rates were low in both the internal and external segments of the globus pallidus, and that firing was irregular in the internal segment of the globus pallidus, compared with firing patterns in offstate parkinsonian patients without dystonia. These firing patterns immediately changed into those of nondystonic, off-state parkinsonism after relief of dystonia These results suggest that off-period dystonia results from the same physiological change in the basal ganglia as that in primary dystonia.
对一名患有关期足部肌张力障碍的帕金森病患者进行了苍白球毁损术。肌张力障碍在手术开始时出现，在首次用微电极穿透苍白球后消失，这可能是微苍白球毁损术的效果。肌张力障碍发作期间的神经元记录显示，与无肌张力障碍的关期帕金森病患者的放电模式相比，苍白球内侧和外侧段的平均放电率均较低，且苍白球内侧段的放电不规则。肌张力障碍缓解后，这些放电模式立即转变为无肌张力障碍的关期帕金森病模式。这些结果表明，关期肌张力障碍与原发性肌张力障碍一样，是由基底神经节相同的生理变化引起的。
