Brandel J P, Peoc'h K, Beaudry P, Welaratne A, Bottos C, Agid Y, Laplanche J L
Centre National de Référence de la MCJ iatrogène, H pital de la Salpêtrière, INSERM U360, Paris, France.
Ann Neurol. 2001 Feb;49(2):257-60. doi: 10.1002/1531-8249(20010201)49:2<257::aid-ana48>3.0.co;2-x.
The usefulness of the detection of 14-3-3 protein in the cerebrospinal fluid (CSF) in the diagnosis of Creutzfeldt-Jakob disease transmitted from human growth hormone was evaluated in 20 French patients. The 14-3-3 protein was rarely detectable within the first 3 months of the disease but always positive after 7 months associated with the aggravation of the disease and the occurrence of dementia. 14-3-3 detection was not predictive of the survival time of the patients. The genotype at PRNP codon 129 could influence the timing of appearance of the 14-3-3 protein in the CSF.
在20名法国患者中评估了检测脑脊液（CSF）中14-3-3蛋白在诊断由人生长激素传播的克雅氏病中的作用。在疾病的前3个月内很少能检测到14-3-3蛋白，但在7个月后总是呈阳性，这与疾病的加重和痴呆的发生有关。14-3-3检测不能预测患者的生存时间。PRNP密码子129处的基因型可能会影响CSF中14-3-3蛋白出现的时间。
