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[俯卧位肺通气治疗心脏外科术后急性呼吸窘迫综合征患者的疗效]

[Results of the treatment of cardiac surgery patients with postoperative acute respiratory distress syndrome by prone-position pulmonary ventilation].

作者信息

Eremenko A A, Egorov V M, Levikov D I

出版信息

Anesteziol Reanimatol. 2000 Sep-Oct(5):42-5.

Abstract

Prone position ventilation (PPV) became an effective method of management of ARDS since 1974. Its positive effects on arterial oxygenation have been amply described, but its impact on the results of treatment and hospital mortality remains a disputable point. We observed 2 groups of patients, 36 pts. each, with ARDS after cardiovascular surgery. The main causes of ARDS were shock syndrome, massive blood loss and transfusion, previous COPD, and postcardiopulmonary bypass ALI. Because of impaired lung function (PaO2/FiO2 < 200), all patients were supported by special methods of ventilation including PEEP, high FiO2, and PCV with inverse I:E ratio. In the main group, PPV was started on days 3.6 +/- 1.2 postoperation. Daily duration of PPV was 4-12 h, after which the patients were turned into a supine position. Controls were treated in a supine position. The groups were identical by age, sex, types of surgery, severity of ARF, and manifestations of MOSF. PPV improved lung function and arterial oxygenation. Clinical outcomes were better in the PPV group than in the controls: a lower frequency of threatening arrhythmia, better results of MOSF treatment, and lower mortality (69 and 33.4%, respectively). Prone position is an effective measure improving arterial oxygenation in patients with ARDS after cardiovascular surgery. The main results of PPV are decrease in complications induced by hypoxia and higher survival rate.

摘要

自1974年以来,俯卧位通气(PPV)成为治疗急性呼吸窘迫综合征(ARDS)的一种有效方法。其对动脉氧合的积极作用已有充分描述,但其对治疗结果和医院死亡率的影响仍是一个有争议的问题。我们观察了两组患者,每组36例,均为心血管手术后发生ARDS的患者。ARDS的主要病因包括休克综合征、大量失血和输血、既往慢性阻塞性肺疾病(COPD)以及体外循环后急性肺损伤(ALI)。由于肺功能受损(动脉血氧分压/吸入氧分数值[PaO2/FiO2]<200),所有患者均采用包括呼气末正压通气(PEEP)、高吸入氧分数值(FiO2)以及反比吸气:呼气(I:E)比的压力控制通气(PCV)等特殊通气方法进行支持治疗。在主要治疗组中,PPV于术后3.6±1.2天开始。PPV每日持续时间为4 - 12小时,之后患者转为仰卧位。对照组采用仰卧位治疗。两组在年龄、性别、手术类型、急性呼吸衰竭(ARF)严重程度以及多器官功能障碍综合征(MOSF)表现方面相同。PPV改善了肺功能和动脉氧合。PPV组的临床结局优于对照组:威胁性心律失常的发生率更低、MOSF治疗效果更好且死亡率更低(分别为69%和33.4%)。俯卧位是改善心血管手术后ARDS患者动脉氧合的有效措施。PPV的主要结果是减少缺氧引起的并发症并提高生存率。

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