Suppr超能文献

[俯卧位肺通气对心脏手术术后呼吸功能不全患者肺氧合功能及血流动力学参数的影响]

[Effects of ventilation of the lungs in prone position on the pulmonary oxygenation function and hemodynamic parameters of heart surgery patients with respiratory insufficiency in the postoperative period].

作者信息

Eremenko A A, Levikov D I, Egorov V M, Ziulaeva T P, Chaus N I

出版信息

Anesteziol Reanimatol. 1998 May-Jun(3):42-5.

PMID:9693433
Abstract

Effect of ventilation in the face-down position (VFDP) on the oxygenation function of the lungs and hemodynamics is studied in 32 patients (aged 22-64 years) subjected to open-heart surgery complicated by development of acute respiratory failure (RF). In 23 patients with grave respiratory distress syndrome, VFDP was performed with forced ventilation of the lungs (FVL) and in 9 with less grave RF, with noninvasive mask ventilation of the lung (NIMVL). Body position of patients on FVL was changed every 4-12 h, of nonintubated patients, 45-60 min. The oxygenation function of the lungs improved in the intubated patients as early as during the first hour of FVL in the face-down position: PaO2/FiO2 notably increased and a tendency to decrease of A-aDO2 and Qs/Qt was observed. The positive effect was maximal after at least 4-hour FVP in the face-down position: PaO2/FiO2 increased by 76.6%, intrapulmonary shunting fraction decreased by 43%, and the O2 alveolar-arterial difference decreased by 27% in comparison with the initial values. After body position of patients was changed, the above improvements did not disappear, despite a slight decrease of the effect attained. VFDP with NIMVL led to similar results: O2 alveolar-arterial gradient decreased, PaO2/FiO2 decreased by 24.2%, the mean values of this ratio approaching the norm. Positive effect somewhat decreased after catecholamines were discontinued, but the oxygenation function of the lungs remained better than initially.

摘要

对32例(年龄22 - 64岁)接受心脏直视手术并发急性呼吸衰竭(RF)的患者,研究了俯卧位通气(VFDP)对肺氧合功能和血流动力学的影响。23例患有严重呼吸窘迫综合征的患者采用肺强制通气(FVL)进行VFDP,9例RF较轻的患者采用无创面罩通气(NIMVL)进行VFDP。接受FVL的患者每4 - 12小时改变体位,未插管患者每45 - 60分钟改变体位。对于插管患者,在俯卧位进行FVL的第一小时内,肺氧合功能就有所改善:PaO2/FiO2显著升高,同时观察到A-aDO2和Qs/Qt有下降趋势。在俯卧位至少进行4小时FVP后,积极效果达到最大:与初始值相比,PaO2/FiO2升高76.6%,肺内分流分数降低43%,氧肺泡-动脉差值降低27%。患者体位改变后,上述改善并未消失,尽管效果略有下降。采用NIMVL的VFDP也得到了类似结果:氧肺泡-动脉梯度降低,PaO2/FiO2降低24.2%,该比值的平均值接近正常。停用儿茶酚胺后积极效果略有下降,但肺氧合功能仍比初始时更好。

文献检索

告别复杂PubMed语法,用中文像聊天一样搜索,搜遍4000万医学文献。AI智能推荐,让科研检索更轻松。

立即免费搜索

文件翻译

保留排版,准确专业,支持PDF/Word/PPT等文件格式,支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述,25分钟生成高质量综述,智能提取关键信息,辅助科研写作。

立即免费体验