Ishikawa S, Mizushima M, Furuta M, Ishikawa A, Kawamura K
Department of Rehabilitation, Higashi Osaka Hospital, 1-7-22 Chuo, Joto-ku, Osaka 536-0005, Japan.
Int J Lepr Other Mycobact Dis. 2000 Sep;68(3):258-66.
This study was conducted to determine if osteoporosis in male leprosy patients is caused by testicular atrophy. Bone volume (BV/TV), trabecular number (TbN), trabecular thickness (TbTh), and trabecular separation (TbSp) were measured in two areas in decalcified paraffin sections of lumbar bones from 29 male leprosy and 6 male nonleprosy autopsy cases. We found significant differences in the average BV/TV measurements among the 7 patients with nodular Leydig cell hyperplasia (BV/TV 12.24%) and the 22 patients without hyperplasia (BV/TV 7.35%) and 6 patients without leprosy (BV/TV 12.98%). Bone volume was maintained in patients with nodular Leydig cell hyperplasia, and we determined no clinical factor other than the Leydig cell hyperplasia that reflected the bone volume. The osteoporosis of male leprosy patients was attributed to secondary gonadal dysfunction due to testicular atrophy, and Leydig cell hyperplasia appears to preserve bone volume.
本研究旨在确定男性麻风病患者的骨质疏松是否由睾丸萎缩引起。对29例男性麻风病尸检病例和6例男性非麻风病尸检病例腰椎脱钙石蜡切片中的两个区域测量骨体积（BV/TV）、骨小梁数量（TbN）、骨小梁厚度（TbTh）和骨小梁间距（TbSp）。我们发现，7例结节性莱迪希细胞增生患者（BV/TV 12.24%）、22例无增生患者（BV/TV 7.35%）和6例无麻风病患者（BV/TV 12.98%）的平均BV/TV测量值存在显著差异。结节性莱迪希细胞增生患者的骨体积得以维持，且我们未发现除莱迪希细胞增生外反映骨体积的临床因素。男性麻风病患者的骨质疏松归因于睾丸萎缩导致的继发性性腺功能障碍，而莱迪希细胞增生似乎可维持骨体积。
