Drug Ther Bull. 2000 Dec;38(12):93-5. doi: 10.1136/dtb.2000.381293.
The cytochrome P450 system is a group of enzymes, found mainly in the liver and gut mucosa, that controls the concentrations of many endogenous substances and drugs. The activity of the individual enzymes can vary over time and from person to person in response to diet, medicines or exposure to environmental pollutants. Here, we review the cytochrome P450 system and consider its relevance to prescribing.
细胞色素P450系统是一组主要存在于肝脏和肠道黏膜中的酶，它控制着许多内源性物质和药物的浓度。个体酶的活性会随着时间的推移以及因饮食、药物或接触环境污染物而在人与人之间有所不同。在此，我们综述细胞色素P450系统，并探讨其与处方开具的相关性。
