Touw D J
Department of Pharmacy, University Hospital Vrije Universiteit, Amsterdam, The Netherlands.
Drug Metabol Drug Interact. 1997;14(2):55-82.
Hepatic oxidation is a major drug metabolising process and is carried out by the cytochrome P-450 monooxygenase system. This system consists of a variety of isoenzymes among which the cytochromes 1A2, 2C8, 2C9/10, 2C19, 2D6, 2E1 and 3A4 are involved in the oxidative metabolism of drugs. Interindividually, large differences in capacities are found. These differences are partly due to genetic constitution (genetic polymorphism, which has been proved to exist for CYP2D6 and CYP2C19) and partly due to environmental factors, among which the administration of interfering drugs can play a major role.
肝脏氧化是主要的药物代谢过程，由细胞色素P-450单加氧酶系统执行。该系统由多种同工酶组成，其中细胞色素1A2、2C8、2C9/10、2C19、2D6、2E1和3A4参与药物的氧化代谢。个体之间存在很大的能力差异。这些差异部分归因于遗传构成（遗传多态性，已证明CYP2D6和CYP2C19存在遗传多态性），部分归因于环境因素，其中干扰药物的使用可能起主要作用。
