[Relationship of the reticulo-plasmocytic reaction of the bone marrow and serum hypergammaglobulinemia when tetracycline is administered to rabbits].

Administration of tetracycline to rabbits in doses of 10 and 40 mg/kg induced hyperplasia of the reticulo-plasmic tissue of the bone marrow correlating with increased levels of gammaglobulins in the blood serum. The pronounced reticulo-plasmocytal reaction of the bone marrow must be considered as manifestation of hyperplasia of the whole reticulo-histiocytal system of the host with impairement of differentiation of the reticular syncytium of the bone marrow.