Stetsenko O N, Poberiĭ I A, Ul'ianov M I, Lindner D P
Antibiotiki. 1981 Nov;26(11):856-60.
Tetracycline was administered orally in daily doses of 20 or 40 mg to 50 practically healthy male chinchilla rabbits weighing 2-2.5 kg. The thymus, appendage, spleen, ileocecal, mesenteric and axillary lymph nodes, bone marrow and peripheral blood were examined with the methods of morpho- cytometry. To verify the data the nonparametric criterion U of Wilcoxon-Mann-Whitny and the Student criterion were used. The mean curves reflecting the reaction level in the peripheral immunity system as a whole were plotted with the use of graphical analysis. It was found that tetracycline in doses of 20 and 40 mg induced a significant change in both the central and the peripheral immunity organs. Two trends in the development of the reaction in the system of immunogenesis were observed: (a) activation, transformation and differentiation of immunocompetent cells and (b) destruction of the cells, particular by transforming and proliferating cells. This gave rise to the depletion of the immunity system which was intensified if the drug was used for a prolonged period of time and in higher doses.
给50只体重2 - 2.5千克、实际健康的雄性毛丝鼠兔口服四环素，每日剂量为20毫克或40毫克。采用形态细胞计量学方法对胸腺、附属器官、脾脏、回盲部、肠系膜和腋窝淋巴结、骨髓及外周血进行检查。为验证数据，使用了威尔科克森 - 曼 - 惠特尼非参数检验标准U和学生检验标准。通过图形分析绘制反映外周免疫系统整体反应水平的平均曲线。结果发现，20毫克和40毫克剂量的四环素均引起中枢和外周免疫器官的显著变化。在免疫发生系统中观察到反应发展的两种趋势：(a)免疫活性细胞的激活、转化和分化；(b)细胞的破坏，特别是转化和增殖细胞的破坏。这导致免疫系统耗竭，如果长期使用该药物且剂量较高，这种耗竭会加剧。
