Haller J A, Shermeta D W, Donahoo J S, White J J
Ann Thorac Surg. 1975 Apr;19(4):365-70. doi: 10.1016/s0003-4975(10)64035-0.
From 1972 through 1974, 5 infants with severe respiratory distress secondary to mediastinal tumors were treated in the Division of Pediatric Surgery of The Johns Hopkins thospital; The mediastinal masses included 2 intramural bronchial cysts, a giant esophageal duplication, a benign teratoma, and a highly malignant neuroblastomamindividualized management was carried out successfully in all: total resection of the bronchial cysts and teratoma; partial resection of the duplication cyst with stripping of the remaining mucosa from the contiguous esophageal wall, thereby preserving esophageal integrity; and excision of involved chest wall and tumor combined with radiotherapy and chemotherapy for the neuroblastoma. This experience emphasizes the potential for lethal respiratory distress from mediastinal tumors in infants and supports the experience reported by others of serious consequences if resection is not performed. Primary physicians and thoracic surgeons must be aware of the lethal potential of such mediastinal tumors among the many other "surgical" causes of respiratory distress in neonates and infants.
1972年至1974年期间，约翰·霍普金斯医院小儿外科收治了5例因纵隔肿瘤继发严重呼吸窘迫的婴儿；纵隔肿块包括2例壁内支气管囊肿、1例巨大食管重复畸形、1例良性畸胎瘤和1例高度恶性神经母细胞瘤。所有病例均成功实施了个体化治疗：支气管囊肿和畸胎瘤行全切除；重复囊肿部分切除，同时从相邻食管壁剥除剩余黏膜，从而保持食管完整性；神经母细胞瘤行受累胸壁和肿瘤切除，并联合放疗和化疗。这一经验强调了婴儿纵隔肿瘤导致致命性呼吸窘迫的可能性，并支持了其他人所报道的不进行切除会产生严重后果的观点。初级医生和胸外科医生必须认识到，在新生儿和婴儿呼吸窘迫的众多其他“外科”病因中，此类纵隔肿瘤具有致命的可能性。
