Tarsy D, Parkes J D, Marsden C D
Arch Neurol. 1975 Feb;32(2):134-6. doi: 10.1001/archneur.1975.00490440084016.
Several theoretical considerations suggest that potentiation of central norepinephrine mechanisms may improve motor performance in patients with Parkinson disease receiving concurrent treatment with levodopa. Clonidine hydrochloride, an antihypertensive drug believed to directly stimulate brain norepinephrine receptors, was administered to a group of patients with relatively mild Parkinson disease and coexisting essential hypertension and to three patients with Parkinson disease manifesting the "on-off" response to levodopa. Although a significant antihypertensive effect was achieved, a change in parkinsonian disability could not be demonstrated.
一些理论上的考虑表明，增强中枢去甲肾上腺素机制可能会改善正在接受左旋多巴联合治疗的帕金森病患者的运动表现。盐酸可乐定是一种被认为可直接刺激脑内去甲肾上腺素受体的抗高血压药物，被给予一组患有相对轻度帕金森病且并存原发性高血压的患者以及三名对左旋多巴表现出“开-关”反应的帕金森病患者。虽然取得了显著的降压效果，但帕金森病残疾状况的改变却未能得到证实。
