Normand M M, Wszolek Z K, Klass D W
Department of Neurology, Mayo Clinic, Rochester, MN 55905, USA.
J Clin Neurophysiol. 1995 May;12(3):280-4. doi: 10.1097/00004691-199505010-00005.
Temporal intermittent rhythmic delta activity (TIRDA) has been reported to be highly specific for diagnosing complex partial epilepsy. Of 12,198 electroencephalographic (EEG) recordings performed at the Mayo Clinic between May 1, 1990 and May 1, 1991, 33 records from 27 patients (18 women and nine men; mean age, 41.5 years; range, 13-82 years) showed TIRDA. Clinical seizures were diagnosed in all patients, and complex partial epilepsy was well documented in 23. In a control group of 100 patients without TIRDA and matched for age and sex, generalized seizures were diagnosed in 25 and partial seizures in 15. Differences between TIRDA and control groups were highly statistically significant. Focal temporal sharp waves or spikes occurred in 23 patients with EEG recordings that contained TIRDA; three of these patients also exhibited generalized atypical spike-and-wave discharges. Four patients had TIRDA but no other epileptiform activity, although earlier EEGs of three of these patients contained spikes or sharp waves. These findings confirm earlier work, and we conclude that TIRDA represents an important epileptogenic abnormality.
据报道，颞叶间歇性节律性δ活动（TIRDA）对复杂部分性癫痫的诊断具有高度特异性。在1990年5月1日至1991年5月1日期间于梅奥诊所进行的12198份脑电图（EEG）记录中，来自27例患者（18名女性和9名男性；平均年龄41.5岁；范围13 - 82岁）的33份记录显示有TIRDA。所有患者均被诊断为临床癫痫发作，其中23例有复杂部分性癫痫的充分记录。在100例无TIRDA且年龄和性别匹配的对照组患者中，25例被诊断为全身性癫痫发作，15例为部分性癫痫发作。TIRDA组与对照组之间的差异具有高度统计学意义。在23例有TIRDA的EEG记录患者中出现了局灶性颞叶尖波或棘波；其中3例患者还表现出全身性非典型棘慢波放电。4例患者有TIRDA但无其他癫痫样活动，尽管其中3例患者早期的EEG记录中有棘波或尖波。这些发现证实了早期的研究工作，我们得出结论，TIRDA代表一种重要的致痫性异常。
